![]() ![]() We find that overall high mutational loads associate with improved survival, and tumors from responding patients are enriched for mutations in the DNA repair gene BRCA2. We analyzed the somatic mutanomes and transcriptomes of pretreatment melanoma biopsies to identify factors that may influence innate sensitivity or resistance to anti-PD-1 therapy. Electronic address: immune checkpoint blockade provides significant clinical benefits for melanoma patients. 7 Division of Dermatology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-1662, USA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1662, USA David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA.6 Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-1662, USA Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA Division of Surgical Oncology, Department of Surgery, University of California, Los Angeles, CA 90095-1662, USA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1662, USA David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA.5 Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA.4 Department of Surgery, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA.3 Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA.2 Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-1662, USA David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA. ![]()
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![]() ![]() In a unique twist, Euphoria had a fully trained staff working at their adult use dispensary for almost two months before they could sell their first flower out of there. Mehta said it was a challenge adjusting to the new volume of both customers and people on staff. Las Vegas sees 40 times the entire population of Montana in tourists every year. “When we did open, it took a lot of time to just get all the regulations together, then our first grow and then getting everything to pass testing.” “That part has been a fine line to walk, but other than that it’s just been an insane learning experience,” he said. Mehta believes what the industry’s cannabis enthusiasts want from a dispensary might not be exactly what the investors want, so there’s often a tit-for-tat battle. “When we went from our Montana operation to this Vegas operation, we had to adjust to both a lot of rules and regulations and a lot of investor types. “It’s been a lot more than I anticipated,” said Mehta. This week, Cannabis Now spoke with Sahil Mehta, one of Euphoria’s business directors, about what the last year has been like as they’ve adjusted to the demands of one of the biggest recreational cannabis market in the world. When adult-use sales commenced in Nevada last summer, Euphoria was more than ready. In the end, Euphoria won the race and was the first dispensary to open for medical sales in the Las Vegas area. This history provided them with a solid footing to jump through all the hoops Nevada’s regulatory bodies put in front of them. The dispensary opened in the suburbs of Las Vegas on August 24, 2015, and has been steadily cementing their place as one of the most renowned shops in the legendary tourist town ever since.Įuphoria’s team came to Las Vegas a few years ago to open a medical marijuana dispensary, after gaining years of industry experience in Montana. ![]() It’s been nearly eight months since Euphoria Wellness opened their doors to all adults over the age of 21. ![]() ![]() ![]() Later that year, all paid access features were discarded and full use of the site became free of charge, allowing all users to view the full 12-month Market Price History of each item. At the same time, the US$12 per year charge for advanced subscriptions was abolished, as it was felt that the extra features should be made available to all subscribers now that a different revenue stream had been found from sellers and purchasers. It made information available to users who paid for a subscription – though 60 days of information was free – access to the past price items were sold for up to 12 months ago by previous sellers who had sold exactly the same release. In July 2007, a new system for sellers was introduced on the site called Market Price History. In late 2005, the Discogs marketplace was launched. By 2015, Discogs had 37 employees, 3 million users and a monthly traffic of 20 million visits. It was originally started from a computer in Lewandowski's closet and limited to electronic music. The discogs was started in 2000 by Kevin Lewandowski who worked as a programmer at Intel. While the site was originally created with a goal of becoming the largest online database of electronic music, the site now includes releases in all genres on all formats. Database contents are user generated and described in which the New York Times describes as "Wikipedia-like". So, is the best music tagging software which can be used to insert picture into mp3 files, change existing image and update all other song information by uploading your music files.Discogs (short for discographies) is a database of information about audio recordings, including commercial releases, promotional releases, and bootleg or off-label releases. To select multiple files, you can press and hold, or key, or use mouse drag and drop your music files. Either you are on a mac, windows, or a mobile (iPhone/Android/others), all you need is an internet browser where you can visit and change your music tags instantly. The biggest advantage of is that it works on all platforms. ID3v2 has been extended to 3 versions so far, and each new version contains new frame definitions. There are standard frames for containing album cover art, BPM, lyrics, copyright, and arbitrary text and URL data, as well as other tags. Each frame is recognized by an identifier (a three- or four-byte string) and one piece of data. It contains an extensible set of "frames" which is located at the start of the file. ID3v2 very different from ID3v1 if we compare structures of both versions. ![]() There is an advance version of ID3v1 which is ID3v1.1 and it contains slight modification which adds a "track number" field and also there is a slight shortening of the "comment" field. ID3v1 containes fixed set of informational fields and it is stored at the end of an MP3 in form of 128-byte segment. There are two different versions of ID3 that are ID3v1 and ID3v2. ID3 tags are set of information such as the title, artist, album, track number, and some other information that is stored in the MP3 file itself. If you have any other format that you want us to add support, please feel free to contact us, and we will try to add it as soon as possible. supports almost all audio/video formats including mp3, mp4, m4a, flac, aac, ogg, ogv, wma, wav, amr, m4r, 3gp, 3gpp, aiff, mid, mpeg, webm, mov and ts. ![]() Then, on second step, you can change all tags of uploaded music file(s). You are free to upload whatever file type, either it is a video or an audio having any encoding format and our system will converts different media types to mp3, and then insert id3v2 sample tags. It is the best music metadata editor because it allows different music types. ![]() ![]()
![]() ![]() But Anthony Russo is trying to wane those expectations. ![]() Many fans believe we could see him transition into his Red Hulk persona from the comic books. He first made an appearance in 2008's The Incredible Hulk. When the cast for Captain America: Civil War was announced, many were surprised to see the return of William Hurt as General Thaddeus 'Thunderbolt' Ross. In Captain America: Civil War, it is believed that Tony Stark outfits Peter Parker with web-shooters created by Stark Industries. The Andrew Garfield version reverted back to the original web-shooters, which he made in his bedroom. Sam Raimi's iteration of the Peter Parker character gave the wall-crawler organic web-shooters, which deviated from his true origins. When it comes to the costumes in the previous movies, there have never been any real complaints from the fans. But we doubt we'll get to see that version any time soon. Sam Raimi's Spider-Man 3 even introduced the black Spider-Man costume that first appeared in the comics way back in the 80s. And there have sometimes been multiple costumes in one movie. There have been two different big screen Spider-Men so far, with both getting costumes unique to each other. "The film will show a mix of what everyone is waiting for with a little twist. When asked if the movie will show the Red and Gold costume as opposed to the Red and Blue, the Russo brother had this to say. But that has been the case with every superhero in the MCU. So much has been made about Tom Holland's acrobatic skills, that it may come as a surprise that when he's in costume, he will be partially, even sometimes fully CGI. He's not ready yet because so much will be produced with special effects." We're still working on a few things, like the costume. ![]() ![]() And we're very happy with the final result. It was a very experimental process, placing him with the other actors, especially with Downey Jr., we had to learn as we worked. Tom Holland is an amazing Spider-Man, people will love him. We knew it was going to be someone young and it was very important to us because we wanted to give this essence to the character, because he is someone unique to the Marvel Universe. We went through the same process with Spider-Man. "Well, we did a lot of research and experimented with the looks of each character. Asked directly about its inclusion, Anthony Russo had this to say. But no one involved with the movie is being entirely forthcoming on the aspects of unleashing Iron Spider. We'll definitely see him in a costume that looks like what we've seen on screen before. Some speculate that we'll see Peter Parker in a homemade outfit as well as the Iron Spider armor. The other option is that you wear this costume, find Pauly Shore and Sean Astin to do a Captain America and Encino Man crossover.There has long been the notion that Tom Holland will wear two different costumes in Civil War. Just make sure to pair it up with one of our Cap shields, since you're going to need one if you want to protect the Avengers from the Sokovia Accords. You might even intimidate Iron Man when you show up to the battle. The costume is packed full of details from the movie, including stitched-in armor with fiberfill stuffing to give you a muscular look. This Captain America costume for men garbs you up like the Marvel superhero. All you need to do is a little bit of determination and this licensed costume! Now, you might be thinking to yourself, “How do I become like Captain America?” Believe it or not, you don't have to be infused with Super Soldier Serum and you never have to encase yourself in a chunk of frozen ice for decades. It's something that everyone should strive toward. We look up to Captain America's determination to protect freedom, and his best friend. In Steve's case, the world today just doesn't value freedom the same way his generation did. Either way, you might have a hard time adjusting to the modern times. It usually goes one of two ways when you thaw out: you either become the leader of the world's greatest superhero team, like Steve Rogers, A.K.A Captain America, or comical antics ensue a la Encino Man. Spending tons of time frozen in a block of ice will do things to a guy. ![]() ![]() ![]() While much of the timing depends on the ongoing writers strike, there’s a chance that the series could stick with its current pace, with season three arriving in summer 2024. The Bear moves very quickly behind the scenes after receiving a renewal a month after the series premiere, season two arrived after only a year-long hiatus. The show will also likely continue to explore themes of loss and living with grief.Īs for how many seasons The Bear will last, showrunners Chris Storer and Joanna Calo told Variety in January they have a road map for the entire series, but the duo are staying mum on how long they see the show going. Bear is a focused, flexible notes app used by writers, lawyers, chefs, teachers, engineers, students, parents and more Bear has quick organisation, editing tools, and export options to help you write quickly and share anywhere and preserve your privacy with encryption. It’s likely that season three will see the Bear finally open its doors, and hopefully, business will be booming, since Carmy, Sydney (Ayo Edebiri), and the team still have to pay Uncle Jimmy back. Season two ends on friends-and-family night, as the restaurant takes a big step toward opening to the public. Play icon The triangle icon that indicates to play What would season three of The Bear be about? The Bear is also a bona fide awards darling, and it’s expected to receive several nods when this year’s Emmy nominations are announced next month. Though season two just released, the installment garnered early acclaim from critics, and the series is set to gain even more buzz in the coming weeks. Has The Bear been renewed for a third season?įX has yet to confirm a third-season renewal, but the announcement seems pretty much inevitable. Months after the game-changing season-one finale, season two picks up right where the first left off, with Carmy (White) and his team attempting to open a new restaurant, the Bear, just 12 weeks after the closing of his late brother’s sandwich shop, the Original Beef of Chicagoland.įor those who have already torn through the entire second season, including that heart-wrenching finale, here’s what we know about the show’s future so far. The first season of the FX series arrived on Hulu with a bang last summer, as critics and fervent fans propelled the show from a stealth word-of-mouth hit to numerous award nominations (including wins for star Jeremy Allen White). ![]() Sb.Season two of The Bear has finally arrived, with 10 new episodes transforming the fast-paced, stress-filled dramedy about a Chicago beef spot into an introspective, calming character study (which still features some heart-clutching moments). ![]() Sb = CustomSkillBuilder(api_client=DefaultApiClient()) Return handler_input.response_builder.speak(WELCOME_MESSAGE).ask(WHAT_DO_YOU_WANT).response Return is_request_type("LaunchRequest")(handler_input) WHAT_DO_YOU_WANT = "What do you want to ask?"Ĭlass LaunchRequestHandler(AbstractRequestHandler): WELCOME_MESSAGE = "This is Alexa regular speech, followed by the sound effect named Bear Groan Roar " import loggingįrom ask_sdk_core.skill_builder import SkillBuilderįrom ask_sdk_core.dispatch_components import (ĪbstractRequestHandler, AbstractRequestInterceptor, AbstractExceptionHandler)įrom ask_sdk_core.utils import is_intent_name, is_request_typeįrom ask_sdk_core.api_client import DefaultApiClientįrom ask_sdk_core.skill_builder import SkillBuilder, CustomSkillBuilderįrom ask_sdk_core.dispatch_components import AbstractRequestInterceptorįrom ask_sdk_core.dispatch_components import AbstractResponseInterceptorįrom ask_sdk_exception import ServiceExceptionįrom ask_sdk_core.handler_input import HandlerInput Also, how would I make this code into a fully functional Alexa skill? Thank you. I would love it if someone could explain to me the logic behind this code. iPhone iPad Apple Watch iMessage Write in portable Markdown, encrypt your notes, sync notes, organize notes with nested tags, add sketches, pick a beautiful theme, export to a variety of formats. I emailed the amazon developer support and they sent me the following code. ![]() I've tried very hard to figure out how to make my Alexa skill to play audio but I cannot find a solution. ![]() ![]() For any queries, get in touch with the tolling authority over call. It's ideal to update your vehicle and personal information on DMV whenever there is a change.Īlternatively, you can visit the concerned toling agency's online toll payment portal, look for any due toll linked with your license plate and make payment. If you are sure to have used a toll facility without tags and haven't received a bill, it could be that your address with DMV is not updated. You can pay the toll bill with cash, card or online banking as per the directions on the invoice. If you do not have a valid tag while crossing toll plazas in Texas, you should receive a toll bill within a month (varies for different agencies and cases). How do I pay a toll without tags in Texas NationalPass- A multi-protocol tag that considers user as a local customer of the toll roads and offers similar discounts.K-Tag- This is toll tag issued by the Kansas Turnpike Authority and is primarily used for Kansas toll facilities.Call NTTA Customer Service at 972-818-NTTA (6882) or visit the NTTA online. The NTTA processes payments for TollTags, TxTags, and EZ TAGs. PikePass- Primarily used for Oklahoma toll roads, this toll tag is also valid in Texas at the same rate as TxTag. As with other toll roads in the region, the North Texas Tollway Authority (NTTA) handles all billing and related customer service functions for the TEXpress Lanes.EZ TAG- Valid for all lanes of tolled roadways in Texas, this toll tag is issued by The Harris County Toll Road Authority (HCTRA) that accommodate electronic toll collection.TollTag- Similar to TxTag, this tag is issued by The North Texas Tollway Authority (NTTA) allowing motorists to pay tolls without stopping at toll booths.There are bridges on the Mexico-Texas border that only accept cash.) ![]() You can purchase TxTag and it will be good for the whole of Texas at locations. ![]() ![]() ![]() The vibrant nightlife at the hotel offers live shows in the theater and nightclub.īarceló Maya Grand Resort, stay in one hotel and enjoy 4! The excellent All-Inclusive program also allows you to enjoy the sports facilities, swimming pools, and access to the many bars and restaurants in the resort’s 4 hotels. The All-Inclusive program offers snacks and drinks 24 hours a day, as well as access to the hotel's 4 restaurants, including 2 specialty restaurants, a buffet restaurant, and a snack-grill restaurant, as well as 3 bars. Whether you choose a couple’s massage or an individual session, the serene environment, whether indoors or outdoors, will envelop you in tranquility.įrom snorkeling adventures to pampering spa treatments, Secrets Akumal Riviera Maya offers a sanctuary for travelers seeking relaxation, romance, and unlimited indulgence.The hotel also features an incredible U-Spa with an original U-Kids Spa. The skilled therapists at Secrets Spa By Pevonia offer an extensive menu of revitalizing skin and hair treatments, manicures, and pedicures. Treat yourself to a pampering session in this luxurious haven, where a comprehensive range of indulgent treatments awaits.īegin your journey with a visit to the hydrotherapy circuit, which features amenities such as saunas, steam rooms, and invigorating showers. Spanning over 16,000 square feet, Secrets Spa By Pevonia provides an oasis of relaxation and rejuvenation. Whether you’re lounging by the pool, relaxing on the beach, or seeking a more intimate setting, the bars serve an array of cocktails, including exclusive creations, to accompany your unforgettable moments. Secrets Akumal also features seven bars, each offering a distinctive ambiance to suit your preferences. Savor exquisite dishes paired with fine wines at the French gourmet restaurant Bordeaux, or enjoy the vibrant flavors of Asia at Himitsu. If you’re a seafood enthusiast, you can’t miss Oceana, where you can relish fresh seafood delicacies while enjoying the soothing ocean breeze. Enter a world of diverse flavors and impeccable service at the resort’s nine remarkable restaurants, including six à la carte options.įor an authentic taste of Mexican cuisine, head to El Patio, where you can savor traditional à la carte Mexican dishes in a charming ambiance reminiscent of the old world. Unlimited Gastronomic DelightsĪt Secrets Akumal Riviera Maya, culinary experiences are taken to extraordinary heights. Delight in themed nights and beach parties, adding an extra touch of magic to your vacation experience. In the evenings, you can immerse yourself in captivating entertainment with nightly concerts and live music performances. Take part in exciting bike tours, try your hand at archery and rifle shooting, or indulge in a friendly game of beach or pool volleyball. You can embark on an unforgettable snorkeling adventure and swim alongside majestic sea turtles in their natural habitat. While Secrets Akumal offers a tranquil atmosphere perfect for relaxation, it also provides an array of activities and excursions to keep you entertained throughout your stay.įrom thrilling water sports to captivating cultural experiences – there’s something for everyone. By choosing this option, you gain access to exclusive privileges and enjoy an enhanced level of service throughout your stay. If you’re feeling luxurious, you can upgrade to a Preferred Club suite. Featuring a private balcony or terrace, each suite provides a personal sanctuary where you can relax amidst stunning natural surroundings. ![]() ![]() Including them will improve your tracking. As a rule of thumb, a fin placed toward the front of the box will provide more turning maneuverability and a fin placed at the back of the box will provide improved tracking and a straighter line. You can move the fin back or forward in the fin box as you would like. Tighten the set screws until the fin is secure. Line the side fins up so their point is aiming at the back of the board and insert them into the now open slots.ģ. With a hex key or an appropriate Allen wrench, loosen the set screws until they no longer impede putting the side fins into their slots.Ģ. For more on fin placement, go to the section below.ġ. If the fin box allows for movement, p ull the fin to where you would like it to sit in the fin box. The immediate worry that many have about a fin that snaps into place via pressure is that it could come back out the beauty of the universal fin is that it requires pressure from the direction of the bottom of the board and toward the nose, which is not the directionality that cruising through the water will apply.ģ. Below, you see that if the fin is at the front of box on a Paddle North Board, you can easily slip the roller into the slot in the middle of the fin box. Push the end with the roller until it snaps into the fin box channel. Note that the point of the fin should be aimed to the back of the board.Ģ. Line the metal dowel up with the hole in the center of the fin box and place it into the track. Insert the screw and tighten it up until it is snug, but do not over-tighten.ġ. Set the end of the fin with the screw hole into the fin box and line the plate up with the screw hole. Note that the fin should curve with the point toward the back of the board.Ĥ. Line the metal dowel up with the space in the middle of the fin box and set it into the track. Move the plate to the front of the fin box (toward the nose of the board)ģ. Another option is to set the plate without the screw into the space and move it around using the tip of a Phillips screwdriver.Ģ. While the screw is sticking up, you should be able to move the plate where you need it. With the plate loosely secured on the end of the screw, set it into the space in the middle of the box. Pictured below are the screw and plate (left) and quick-release (right) setups.ġ. First, identify what type of fin setup you have. Installing the fin on your paddle board, regardless of type, is a simple process. ![]() ![]() NEW: /r/StupidFood - is it not Friday and you have a picture of some incredibly 'unique', and often absurd combination of food? Feel free to toss that over on /r/StupidFood. Any sort of post pertaining to an odd food or drink opinion should be posted only on Fridays.Posts about general themes, like medicine, are fine, so long as they avoid any mention of the pandemic or resulting effects of it. No posts relating to the 2019/2020 outbreak.We will also manually remove posts that do not give enough detail and explanation of their opinion. All posts must be a minimum of 150 characters.No excessive trolling, targeted harassment, or racism - obey Reddit TOS and abide by Reddiquette: Remember the human.Zero tolerance against racist slurs, blatant bigotry, and excessive bad trolling If you elaborate thoroughly in the text submission - we may make exception. Any opinion promoting or condoning self-harm or violence/abuse will also have zero tolerance. If it sounds like utter BS, like 'I enjoy migraine headaches' - no. We'll make an exception for like 28 days, but within that period no. if a post has been made within the last month, it will be removed.And trust me, if you write all of like 10 words for a text-submission, your post will be short-lived. Yes, some opinions can be rather self-explanatory, but you can definitely explain why in a couple sentences. Fill out the post's text field better explaining an opinion or view.We should be able to know what you're talking about before clicking. None of this "Wearing shoes."-type nonsense. Be clear and concise in your post titles' opinion/view, and avoid being either vague or nebulous in your opinions point.Failure to do so will resort in post removal. ![]() In terms of cultural or social topics, such as sexuality/gender, religion, or the human experience - **please make use of the "Discussion Thread" flair since those threads are more strictly moderated. In the event you feel the post is just low quality or has flawed logic, downvote the pinned QualityVote bot comment, but only if the post is really just not good at all, not because you disagree. It's the golden rule: Upvote if you disagree - downvote if you agree. Expert Analysis - Those who are writing text-walls about why they think what they do.Sports - When it's no longer 'just a game'.Gaming - This can include board games too!.Include a picture for proof if it's just a weird food combination. ![]()
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