![]() ![]() We find that overall high mutational loads associate with improved survival, and tumors from responding patients are enriched for mutations in the DNA repair gene BRCA2. We analyzed the somatic mutanomes and transcriptomes of pretreatment melanoma biopsies to identify factors that may influence innate sensitivity or resistance to anti-PD-1 therapy. Electronic address: immune checkpoint blockade provides significant clinical benefits for melanoma patients. 7 Division of Dermatology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-1662, USA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1662, USA David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA.6 Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-1662, USA Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA Division of Surgical Oncology, Department of Surgery, University of California, Los Angeles, CA 90095-1662, USA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1662, USA David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA.5 Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA.4 Department of Surgery, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA.3 Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA.2 Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-1662, USA David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA. ![]()
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